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Contrave is a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of more than one active ingredient, that might make them more effective and safer. Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that as of right now there are no long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise hypertension and heartrate, and really should not be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. Approving a drug using this type of many potentially lethal negative effects is inconsistent with the mission statement from the FDA. The power of the drug manufacturing lobby is blatantly evident inside the approval of many drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety within the US.

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